Multi-stage Feature Selection Research Articles

CAFé'S PERFORMANCE MODELING WITH SPATIAL DATA

The relevance of the article lies in the importance of the placement problem for the economic performance of organizations and the growth of interest in the use of spatial data in decision support systems in recent years. The main purpose of the research work is to model the estimation of impact of important spatial features for café's turnover prediction. The article analyzes some approaches that combine spatial data with machine learning to solve the placement problem. A correlation analysis of spatial data has been carried out. A multistage feature selection for two sets of features proper for different types of models was made. The hyperparameter optimization for the selected modeling methods (linear regression, decision tree, random forest, gradient boosting) was made and models were created. The main tools are the Python programming language and its libraries pandas, sklearn, XGBoost, hyperopt, shap, boostaroota. The analysis of the obtained results was carried out. The gradient boosting model was identified as optimal in terms of accuracy and interpretation. The result of the work is the created approach to modeling the economic performance of a company using machine learning based on spatial data.

Multi-stage biomedical feature selection extraction algorithm for cancer detection

Cancer is a significant cause of death worldwide. Early cancer detection is greatly aided by machine learning and artificial intelligence (AI) to gene microarray data sets (microarray data). Despite this, there is a significant discrepancy between the number of gene features in the microarray data set and the number of samples. Because of this, it is crucial to identify markers for gene array data. Existing feature selection algorithms, however, generally use long-standing, are limited to single-condition feature selection and rarely take feature extraction into account. This work proposes a Multi-stage algorithm for Biomedical Deep Feature Selection (MBDFS) to address this issue. In the first, three feature selection techniques are combined for thorough feature selection, and feature subsets are obtained; in the second, an unsupervised neural network is used to create the best representation of the feature subset to enhance final classification accuracy. Using a variety of metrics, including a comparison of classification results before and after feature selection and the performance of alternative feature selection methods, we evaluate MBDFS's efficacy. The experiments demonstrate that although MBDFS uses fewer features, classification accuracy is either unchanged or enhanced.

Data Normalization Methods of Hybridized Multi-Stage Feature Selection Classification for 5G Base Station Antenna Health Effect Detection

It is essential to assess human exposure to Fifth Generation (5G) Radiofrequency Electromagnetic Field (RF-EMF) signal from Base Station (BS) sources operating at Low Band 5G at 700 MHz, Sub-6 Band 5G at 3.5 GHz, and Millimeter Wave (mmWave) 5G at 28 GHz. This assessment will help determine whether 5G technology is safe for people. Inconsistent results were found in previous epidemiological studies on the health effects of radiation exposure from Mobile Phones (MP) and BS when normalization methods were used to prepare the data for Machine Learning (ML), which could lead to misclassification because of the dataset's quality. The effects on adult health are assessed in terms of physiological parameters (body temperature, heart rates, and blood pressure), cognitive performance (brain memory, motor control, and attention), Visual Analogue Scales (VAS) for well-being parameter, and Electromagnetic Field (EMF) perception parameter. The purpose of the research was to identify changes in the physiological parameters of adult individuals before, during, or after exposure to 5G signals, including Sham (No Exposure). 12 normalization methods are selected which are Z-score normalization (z score), Linear scaling (LS), Binary normalization (BNN), Bipolar normalization (BPN), Min-Max scaling (MMS), t-score normalization (t score), Decimal Inverse Logarithmic Scaled Normalization (DILSN), Relative Mean Normalization (RMN), Relative Standard Deviation Normalization (RSDN), Variation Normalization (VN), Robust Normalization (RN) and Relative Interquartile Normalization (RIN) and based on their F-value and p-value analyses, the three best normalization techniques are selected in this research. The original distribution of each parameter data variable is different, these techniques are beneficial for converting data so that it is dimensionless and has equivalent distributions. Based on the selection criteria for the hybridized Multi-Stage Feature Selection (MSFS) classification for 5G base station antenna health effect detection, BNN, MMS, and RSDN were named as the top three normalization techniques.

Data-driven audiogram classifier using data normalization and multi-stage feature selection

Audiograms are used to show the hearing capability of a person at different frequencies. The filter bank in a hearing aid is designed to match the shape of patients’ audiograms. Configuring the hearing aid is done by modifying the designed filters’ gains to match the patient’s audiogram. There are few problems faced in achieving this objective successfully. There is a shortage in the number of audiologists; the filter bank hearing aid designs are complex; and, the hearing aid fitting process is tiring. In this work, a machine learning solution is introduced to classify the audiograms according to the shapes based on unsupervised spectral clustering. The features used to build the ML model are peculiar and describe the audiograms better. Different normalization methods are applied and studied statistically to improve the training data set. The proposed Machine Learning (ML) algorithm outperformed the current existing models, where, the accuracy, precision, recall, specificity, and F-score values are higher. The reason for the better performance is the use of multi-stage feature selection to describe the audiograms precisely. This work introduces a novel ML technique to classify audiograms according to the shape, which, can be integrated to the future and existing studies to change the existing practices in classifying audiograms.

Early Diagnosis of Parkinson's Disease Exploting Motor and Non-Motor Symptoms: Results from the PPMI Cohort

Parkinson's is a neurodegenerative disease, with a slow but progressive evolution, which involves some main functions such as the control of movements and balance. Symptoms vary by patient and include motor factors such as tremors and stiffness as well as non-motor symptoms such as cognitive impairment. Its diagnosis is not easy, so it is becoming increasingly necessary to assist doctors in identifying and predicting the disease. Artificial intelligence takes up this challenge and this work proposes a new approach to predict the onset of the disease and monitor patients. The experimentation involved the use of different classification algorithms. The proposed methodology was validated on a large ad hoc data set by compiling data collected by the Parkinson's Progression Markers Initiative (PPMI). Specifically, the study compares the results of the classification taking into consideration only the characteristics belonging to the motor sphere, or those of the non-motor sphere, with the aim of understanding which characteristics are more significant for the identification of the disease. In this regard, a multi-stage feature selection was conducted and SHAP was used to make the model explainable.

Optimized Intelligent Classifier for Early Breast Cancer Detection Using Ultra-Wide Band Transceiver.

Breast cancer is the most common cancer diagnosed in women and the leading cause of cancer-related deaths among women worldwide. The death rate is high because of the lack of early signs. Due to the absence of a cure, immediate treatment is necessary to remove the cancerous cells and prolong life. For early breast cancer detection, it is crucial to propose a robust intelligent classifier with statistical feature analysis that considers parameter existence, size, and location. This paper proposes a novel Multi-Stage Feature Selection with Binary Particle Swarm Optimization (MSFS-BPSO) using Ultra-Wideband (UWB). A collection of 39,000 data samples from non-tumor and with tumor sizes ranging from 2 to 7 mm was created using realistic tissue-like dielectric materials. Subsequently, the tumor models were inserted into the heterogeneous breast phantom. The breast phantom with tumors was imaged and represented in both time and frequency domains using the UWB signal. Consequently, the dataset was fed into the MSFS-BPSO framework and started with feature normalization before it was reduced using feature dimension reduction. Then, the feature selection (based on time/frequency domain) using seven different classifiers selected the frequency domain compared to the time domain and continued to perform feature extraction. Feature selection using Analysis of Variance (ANOVA) is able to distinguish between class-correlated data. Finally, the optimum feature subset was selected using a Probabilistic Neural Network (PNN) classifier with the Binary Particle Swarm Optimization (BPSO) method. The research findings found that the MSFS-BPSO method has increased classification accuracy up to 96.3% and given good dependability even when employing an enormous data sample.

Explainable Multi-Class Classification Based on Integrative Feature Selection for Breast Cancer Subtyping

Breast cancer subtype classification is a multi-class classification problem that can be handled using computational methods. Three main challenges need to be addressed. Consider first the high dimensionality of the available datasets relative to the extremely small number of instances. Second, the integration of different levels of data makes the dimensionality problem even more challenging. The third challenging issue is the ability to explain the predictions provided by a machine learning model. Recently, several deep learning models have been proposed for feature extraction and classification. However, due to the small size of the datasets, they were unable to achieve satisfactory results, particularly in multi-class classification. Aside from that, explaining the impact of features on classification has not been addressed in previous works. To cope with these problems, we propose a multi-stage feature selection (FS) framework with two data integration schemes. Using multi-omics data, four machine learning models, namely support vector machines, random forest, extra trees, and XGBoost, were investigated at each level. The SHAP framework was used to explain how specific features influenced classification. Experimental results demonstrated that ensemble models with early integration and two stage feature selection improved results compared to baseline experiments and to state-of-the art methods. Furthermore, more explanations regarding the implications of the main relevant features in the predictions are provided, which could serve as a baseline for future biological investigations.

An unbiased algorithm for objective separation of Alzheimer's, Alzheimer's mixed with cerebrovascular symptomology, and healthy controls from one another using electrovestibulography (EVestG).

Diagnosis of Alzheimer's disease (AD) from AD with cerebrovascular disease pathology (AD-CVD) is a rising challenge. Using electrovestibulography (EVestG)measured signals, we develop an automated feature extraction and selection algorithm for an unbiased identification of AD and AD-CVD from healthy controls as well as their separation from each other. EVestG signals of 24 healthy controls, 16 individuals with AD, and 13 with AD-CVD were analyzed within two separate groupings: One-versus-One and One-versus-All. A multistage feature selection process was conducted over the training dataset using linear support vector machine (SVM) classification with 10-fold cross-validation, k nearest neighbors/averaging imputation, and exhaustive search. The most frequently selected features that achieved highest classification performance were selected. 10-fold cross-validation was applied via a linear SVM classification on the entire dataset. Multivariate analysis was run to test the between population differences while controlling for the covariates. Classification accuracies of ≥ 80% and78% were achieved for the One-versus-All classification approach and AD versus AD-CVD separation, respectively. The results also held true after controlling for the effect of covariates. AD/AD-CVD participants showed smaller/larger EVestG averaged field potential signals compared to healthy controls and AD-CVD/AD participants. These characteristics are in line with our previous study results.

A New Multi-Stage Feature Selection and Classification Approach: Bank Customer Credit Risk Scoring

Abstract Lots of information about customers are stored in the databases of banks. These databases can be used to assess the credit risk. Feature selection is a well-known concept to reduce the dimension of such databases. In this paper, a multi-stage feature selection approach is proposed to reduce the dimension of database of an Iranian bank including 50 features. The first stage of this paper is devoted to removal of correlated features. The second stage of it is allocated to select the important features with genetic algorithm. The third stage is proposed to weight the variables using different filtering methods. The fourth stage selects feature through clustering algorithm. Finally, selected features are entered into the K-nearest neighbor (K-NN) and Decision Tree (DT) classification algorithms. The aim of the paper is to predict the likelihood of risk for each customer based on effective and optimum subset of features available from the customers.

Improving Recurrence Prediction Accuracy of Ovarian Cancer Using Multi-phase Feature Selection Methodology

ABSTRACT Ovarian cancer stands in the sixth position among the most commonly occurring cancers in the world. Because of the high rate of recurrence, this gynecological malignancy seems to be a vital reason behind cancer-related death among women as tumor recurrence stands as an obstacle in ovarian cancer treatment. It is crucial to find those recurrence causing factors in order to plan suitable therapies with high prognostic results. Hence, in this work, a multistage feature selection methodology is proposed to identify key MiRNAs and clinical features for improving the accuracy of ovarian cancer recurrence prediction. MiRNA expression profiles of ovarian cancer patients and their corresponding clinical data were downloaded from the TCGA cancer repository. From 588 MiRNAs, 6 key MiRNAs were selected using the Inheritable Bi-objective Combinatorial Genetic Algorithm (IBCGA) followed by factor analysis. The biological importance of the resultant MiRNAs in cancer and cellular pathways were studied using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Further, recurrence prediction was performed using the obtained MiRNA expression profiles and clinical factors, chosen using correlation analysis. The proposed approach using the selected features yielded a prediction accuracy of 91.86% using the XGBoost classifier while the same without feature selection was 76.59%. Compared to previous similar works, this model provides a better result in terms of accuracy and reveals influential MiRNAs in ovarian cancer.

Multi-stage feature selection (MSFS) algorithm for UWB-based early breast cancer size prediction.

Breast cancer is the most common cancer among women and it is one of the main causes of death for women worldwide. To attain an optimum medical treatment for breast cancer, an early breast cancer detection is crucial. This paper proposes a multi- stage feature selection method that extracts statistically significant features for breast cancer size detection using proposed data normalization techniques. Ultra-wideband (UWB) signals, controlled using microcontroller are transmitted via an antenna from one end of the breast phantom and are received on the other end. These ultra-wideband analogue signals are represented in both time and frequency domain. The preprocessed digital data is passed to the proposed multi- stage feature selection algorithm. This algorithm has four selection stages. It comprises of data normalization methods, feature extraction, data dimensional reduction and feature fusion. The output data is fused together to form the proposed datasets, namely, 8-HybridFeature, 9-HybridFeature and 10-HybridFeature datasets. The classification performance of these datasets is tested using the Support Vector Machine, Probabilistic Neural Network and Naïve Bayes classifiers for breast cancer size classification. The research findings indicate that the 8-HybridFeature dataset performs better in comparison to the other two datasets. For the 8-HybridFeature dataset, the Naïve Bayes classifier (91.98%) outperformed the Support Vector Machine (90.44%) and Probabilistic Neural Network (80.05%) classifiers in terms of classification accuracy. The finalized method is tested and visualized in the MATLAB based 2D and 3D environment.

A Computer-Aided Diagnosis System for Lung Cancer Detection with Automatic Region Growing, Multistage Feature Selection and Neural Network Classifier

An effective automatic region growing was developed in this work for the segmentation of suspected lung nodules from the Computed Tomography (CT) lung images. After the segmentation of the suspected lung nodules the eccentricity and area features were calculated to eliminate line like structures and tiny clusters below 3mm. The centroid analysis, contrast, autocorrelation and homogeneity features were extracted for the suspected lung nodules. The extracted features were trained and tested with Artificial Neural Network (ANN) to remove the blood vessels and calcifications (calcium deposition in the lungs). This work was carried out on 106 patients images retrospectively collected from Bharat Scans, Chennai, which had 56 cancerous nodules and 745 non-cancerous nodules (size greater than 3 mm). The proposed work yielded sensitivity, specificity and accuracy of 100%, 93% and 94%, respectively.

Detection of congestive heart failure from short-term heart rate variability segments using hybrid feature selection approach

ObjectivesThe aim of this work is to investigate the accuracy limits of automated detection of congestive heart failure (CHF) from short-term heart rate variability (HRV) series. Short-term HRV analysis uses 5-minute segments from HRV recordings to diagnose a disorder. This work proposes a hybrid feature selection procedure aimed at finding highly accurate models containing only a few highly informative features, which enables physiological interpretation of the features relevant for the model. Materials and methodsShort-term HRV segments are analyzed for CHF diagnosis. Subjects' records from four public PhysioNet databases are considered (66 healthy subjects and 42 CHF subjects). The problem is approached from a machine learning perspective, by extracting 111 linear time domain, frequency domain, time-frequency, nonlinear and symbolic dynamics HRV features. A multistage hybrid feature selection method is proposed that eventually eliminates most features. The method uses a symmetrical uncertainty filter, Naive Bayes wrapper with best first search, and final greedy iterative feature elimination. For classification purposes, we use rotation forest (RTF), radial based support vector machines (SVM), random forest (RF), multilayer perceptron artificial neural network, and k-nearest neighbors’ classifiers in order to evaluate the feature sets at each step of the process and to obtain as accurate model as possible. Leave-one-subject-out cross-validation evaluation method was used, with two variants: subject-level (coarse-grained) and feature vector-level (fine-grained). ResultsThe results show that the feature selection method is capable of either improving or retaining the classification accuracy of the full feature set (RTF: subject-level ACC = 88.9%, feature vector-level ACC = 85.6%; SVM: subject-level ACC = 89.8%, feature vector-level ACC = 83.5%; RF: subject-level ACC = 87.0%, feature vector-level ACC = 85.5%), while greatly reducing the number of included features, to only four HRV features for RTF and RF, and only two HRV features for SVM. The resulting best models for subject-level classification achieved are: RTF: ACC = 90.7%, SENS = 78.6%, SPEC = 98.6%, obtained with features: LF/HF ratio, maximum alphabet entropy, alphabet entropy variance, and HaarWaveletSD (scale = 8); SVM: ACC = 88.0%, SENS = 78.6%, SPEC = 93.9%, obtained with features: LF/HF ratio and Rate_U; RF: ACC = 90.7%, SENS = 78.6%, SPEC = 98.6%, obtained with features: LF/HF ratio, maximum alphabet entropy, Rate_U, and Rate_B. Other classifiers provided similar, but somewhat lower results. A comparison of the procedure with the results of individual filter, wrapper, and simple hybrid approaches is provided, which demonstrates the efficiency of the proposed procedure. ConclusionsThe results suggest that the method can achieve accurate generalizable models for automated diagnosis of CHF from short-term HRV segments in subjects with very few informative features. The choice of the best features and the classification results are similar between the three best classifiers, so the use of any of them with the proposed method is recommended. Nonlinear and symbolic dynamics features are shown to have an important role in the resulting models. The presented methodology may be useful for first-hand screening for CHF as well as for similar diagnostic or automated detection problems in biomedicine.

Multistage feature selection approach for high-dimensional cancer data

Cancer is a serious disease that causes death worldwide. DNA methylation (DNAm) is an epigenetic mechanism, which controls the regulation of gene expression and is useful in early detection of cancer. The challenge with DNA methylation microarray datasets is the huge number of CpG sites compared to the number of samples. Recent research efforts attempted to reduce this high dimensionality by different feature selection techniques. This article proposes a multistage feature selection approach to select the optimal CpG sites from three different DNAm cancer datasets (breast, colon and lung). The proposed approach combines three different filter feature selection methods including Fisher Criterion, t-test and Area Under ROC Curve. In addition, as a wrapper feature selection, we apply genetic algorithms with Support Vector Machine Recursive Feature Elimination (SVM-RFE) as its fitness function, and SVM as its evaluator. Using the Incremental Feature Selection (IFS) strategy, subsets of 24, 13 and 27 optimal CpG sites are selected for the breast, colon and lung cancer datasets, respectively. By applying fivefold cross-validation on the training datasets, these subsets of optimal CpG sites showed perfect classification accuracies of 100, 100 and 97.67%, respectively. Moreover, the testing of the three independent cancer datasets by these final subsets resulted in accuracies 96.02, 98.81 and 94.51%, respectively. The experimental results demonstrated high classification performance and small optimal feature subsets. Consequently, the biological significance of the genes corresponding to these feature subsets is validated using enrichment analysis.

Multi-Stage Feature Selection Based Intelligent Classifier for Classification of Incipient Stage Fire in Building.

In this study, an early fire detection algorithm has been proposed based on low cost array sensing system, utilising off- the shelf gas sensors, dust particles and ambient sensors such as temperature and humidity sensor. The odour or “smellprint” emanated from various fire sources and building construction materials at early stage are measured. For this purpose, odour profile data from five common fire sources and three common building construction materials were used to develop the classification model. Normalised feature extractions of the smell print data were performed before subjected to prediction classifier. These features represent the odour signals in the time domain. The obtained features undergo the proposed multi-stage feature selection technique and lastly, further reduced by Principal Component Analysis (PCA), a dimension reduction technique. The hybrid PCA-PNN based approach has been applied on different datasets from in-house developed system and the portable electronic nose unit. Experimental classification results show that the dimension reduction process performed by PCA has improved the classification accuracy and provided high reliability, regardless of ambient temperature and humidity variation, baseline sensor drift, the different gas concentration level and exposure towards different heating temperature range.

Outcome Prediction for Patient with High-Grade Gliomas from Brain Functional and Structural Networks.

High-grade glioma (HGG) is a lethal cancer, which is characterized by very poor prognosis. To help optimize treatment strategy, accurate preoperative prediction of HGG patient's outcome (i.e., survival time) is of great clinical value. However, there are huge individual variability of HGG, which produces a large variation in survival time, thus making prognostic prediction more challenging. Previous brain imaging-based outcome prediction studies relied only on the imaging intensity inside or slightly around the tumor, while ignoring any information that is located far away from the lesion (i.e., the "normal appearing" brain tissue). Notably, in addition to altering MR image intensity, we hypothesize that the HGG growth and its mass effect also change both structural (can be modeled by diffusion tensor imaging (DTI)) and functional brain connectivities (estimated by functional magnetic resonance imaging (rs-fMRI)). Therefore, integrating connectomics information in outcome prediction could improve prediction accuracy. To this end, we unprecedentedly devise a machine learning-based HGG prediction framework that can effectively extract valuable features from complex human brain connectome using network analysis tools, followed by a novel multi-stage feature selection strategy to single out good features while reducing feature redundancy. Ultimately, we use support vector machine (SVM) to classify HGG outcome as either bad (survival time ≤ 650 days) or good (survival time >650 days). Our method achieved 75 % prediction accuracy. We also found that functional and structural networks provide complementary information for the outcome prediction, thus leading to increased prediction accuracy compared with the baseline method, which only uses the basic clinical information (63.2 %).

Multi-Stage Feature Selection by Using Genetic Algorithms for Fault Diagnosis in Gearboxes Based on Vibration Signal

There are growing demands for condition-based monitoring of gearboxes, and techniques to improve the reliability, effectiveness and accuracy for fault diagnosis are considered valuable contributions. Feature selection is still an important aspect in machine learning-based diagnosis in order to reach good performance in the diagnosis system. The main aim of this research is to propose a multi-stage feature selection mechanism for selecting the best set of condition parameters on the time, frequency and time-frequency domains, which are extracted from vibration signals for fault diagnosis purposes in gearboxes. The selection is based on genetic algorithms, proposing in each stage a new subset of the best features regarding the classifier performance in a supervised environment. The selected features are augmented at each stage and used as input for a neural network classifier in the next step, while a new subset of feature candidates is treated by the selection process. As a result, the inherent exploration and exploitation of the genetic algorithms for finding the best solutions of the selection problem are locally focused. The approach is tested on a dataset from a real test bed with several fault classes under different running conditions of load and velocity. The model performance for diagnosis is over 98%.

Analysis of network traffic features for anomaly detection

Anomaly detection in communication networks provides the basis for the uncovering of novel attacks, misconfigurations and network failures. Resource constraints for data storage, transmission and processing make it beneficial to restrict input data to features that are (a) highly relevant for the detection task and (b) easily derivable from network observations without expensive operations. Removing strong correlated, redundant and irrelevant features also improves the detection quality for many algorithms that are based on learning techniques. In this paper we address the feature selection problem for network traffic based anomaly detection. We propose a multi-stage feature selection method using filters and stepwise regression wrappers. Our analysis is based on 41 widely-adopted traffic features that are presented in several commonly used traffic data sets. With our combined feature selection method we could reduce the original feature vectors from 41 to only 16 features. We tested our results with five fundamentally different classifiers, observing no significant reduction of the detection performance. In order to quantify the practical benefits of our results, we analyzed the costs for generating individual features from standard IP Flow Information Export records, available at many routers. We show that we can eliminate 13 very costly features and thus reducing the computational effort for on-line feature generation from live traffic observations at network nodes.

A Multistage Feature Selection Model for Document Classification Using Information Gain and Rough Set

Huge number of documents are increasing rapidly, therefore, to organize it in digitized form text categorization becomes an challenging issue. A major issue for text categorization is its large number of features. Most of the features are noisy, irrelevant and redundant, which may mislead the classifier. Hence, it is most important to reduce dimensionality of data to get smaller subset and provide the most gain in information. Feature selection techniques reduce the dimensionality of feature space. It also improves the overall accuracy and performance. Hence, to overcome the issues of text categorization feature selection is considered as an efficient technique . Therefore, we, proposed a multistage feature selection model to improve the overall accuracy and performance of classification. In the first stage document preprocessing part is performed. Secondly, each term within the documents are ranked according to their importance for classification using the information gain. Thirdly rough set technique is applied to the terms which are ranked importantly and feature reduction is carried out. Finally a document classification is performed on the core features using Naive Bayes and KNN classifier. Experiments are carried out on three UCI datasets, Reuters 21578, Classic 04 and Newsgroup 20. Results show the better accuracy and performance of the proposed model.

A novel multi-stage feature selection method for microarray expression data analysis

With the development of genome research, finding method to classify cancer and detect biomarkers efficiently has become a challenging problem. In this paper, a novel multi-stage method for feature selection is proposed which considers all kinds of genes in the original gene set. The method eliminates the irrelevant, noisy and redundant genes and selects a subset of relevant genes at different stages. The proposed method is examined on microarray datasets of Leukemia, Prostate, Colon, Breast, Nervous and DLBCL by different classifiers and the best accuracies of the method in these datasets are 100%, 98.04%, 100%, 89.74%, 100% and 98.28%, respectively.